This product is the carrier free version of product #61964. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.

This formulation is ideal for use with technologies requiring specialized or custom antibody labeling, including fluorophores, metals, lanthanides, and oligonucleotides. It is not recommended for ChIP, ChIP-seq, CUT&RUN or CUT&Tag assays. If you require a carrier free formulation for chromatin profiling, please contact us. Optimal dilutions/concentrations should be determined by the end user.

BSA and Azide Free antibodies are quality control tested by size exclusion chromatography (SEC) to determine antibody integrity.

Formulation

Supplied in 1X PBS (10 mM Na₂HPO₄, 3 mM KCl, 2 mM KH₂PO₄, and 140 mM NaCl (pH 7.8)). BSA and Azide Free.

For standard formulation of this product see product #61964

Storage

Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.

Specificity / Sensitivity

COL14A1 (E5W8S) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total COL14A1 protein.

Species Reactivity:

Human

Source / Purification

Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human COL14A1 protein.

Background

COL14A1 (Collagen Type XIV, Undulin) is an interstitial collagen that belongs to the fibril-associated collagens with interrupted triple helices (FACIT) family (1). COL14A1 contributes to the assembly and remodeling of the interstitial extracellular matrix, in part by promoting the formation of inter-molecular bridges between collagen molecules (2-4). Changes in COL14A1 expression have been identified as a potential biomarker in a variety of fibrotic diseases, including idiopathic pulmonary fibrosis (5,6) and fibrotic kidney diseases (7). A study of tumor stroma-associated biomarkers furthermore revealed that COL14A1 was one of a group of genes whose expression correlated negatively with clinical stage of breast cancer patient samples (8).

Database Links

UniProt ID: Q05707

Entrez-Gene Id: 7373

限制使用

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For Research Use Only. Not For Use In Diagnostic Procedures.

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COL14A1 (E5W8S) Rabbit mAb (BSA and Azide Free) #58865

Supporting Data

Application Key:

Species Cross-Reactivity Key:

Product Information

Product Usage Information