Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
Aromatase (D5Q2Y) Rabbit mAb (BSA and Azide Free) #64970
Filter:
- WB
- IHC
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 50 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
- IHC-Immunohistochemistry
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Description
| MW (kDa) | 50 |
Product Usage Information
This product is the carrier free version of product #14528. All data were generated using the same antibody clone in the standard formulation which contains BSA and glycerol.
Formulation
Supplied in 1X PBS (10 mM Na
Storage
Store at -20°C. This product will freeze at -20°C so it is recommended to aliquot into single-use vials to avoid multiple freeze/thaw cycles. A slight precipitate may be present and can be dissolved by gently vortexing. This will not interfere with antibody performance.
Specificity / Sensitivity
Aromatase (D5Q2Y) Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total aromatase protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human aromatase protein.
Background
Aromatase is a member of the cytochrome P450 superfamily of enzymes, which are monooxygenases that catalyze reactions involved in drug metabolism and cholesterol and steroid synthesis (1,2). Aromatase is responsible for the conversion of testosterone into 17-β estradiol (2). Aromatase is mainly expressed in the brain (3), ovaries (4), and placenta (5). Aromatase plays an important role in development of the central nervous system during ontogenesis (6,7), gonadal development, and sex differentiation (8,9). Research studies have suggested that inhibition of aromatase may be an effective therapeutic strategy for postmenopausal breast cancers that are estrogen receptor positive (6,10). Mutations in the corresponding aromatase gene are associated with cases of aromatase excess syndrome (AEXS) and aromatase deficiency (AROD) disorders (11-14).
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- Chen, S.A. et al. (1988) DNA 7, 27-38.
- Hinshelwood, M.M. et al. (2000) Endocrinology 141, 2050-3.
- Pezzi, V. et al. (2003) J Steroid Biochem Mol Biol 87, 181-9.
- Peruffo, A. et al. (2011) Gen Comp Endocrinol 172, 211-7.
- Montelli, S. et al. (2012) Brain Res 1475, 11-8.
- Kuntz, S. et al. (2003) Cytogenet Genome Res 101, 283-8.
- Ramsey, M. et al. (2007) Differentiation 75, 978-91.
- Hu, Q. et al. (2012) J Med Chem 55, 7080-9.
- Gilani, R.A. et al. (2012) Breast Cancer Res Treat 135, 681-92.
- Ito, Y. et al. (1993) Proc Natl Acad Sci U S A 90, 11673-7.
- Morishima, A. et al. (1995) J Clin Endocrinol Metab 80, 3689-98.
- Carani, C. et al. (1997) N Engl J Med 337, 91-5.
- Fukami, M. et al. (2012) Int J Endocrinol 2012, 584807.
限制使用
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For Research Use Only. Not for Use in Diagnostic Procedures.
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