Recombinant: Superior lot-to-lot consistency, continuous supply, and animal-free manufacturing.
INSM1 (F7P8K) Rabbit mAb #94277
Filter:
- WB
Supporting Data
| REACTIVITY | H |
| SENSITIVITY | Endogenous |
| MW (kDa) | 63 |
| Source/Isotype | Rabbit IgG |
Application Key:
- WB-Western Blotting
Species Cross-Reactivity Key:
- H-Human
Product Information
Product Usage Information
| Application | Dilution |
|---|---|
| Western Blotting | 1:1000 |
Storage
Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Protocol
Specificity / Sensitivity
INSM1 (F7P8K) Rabbit mAb recognizes endogenous levels of total INSM1 protein.
Species Reactivity:
Human
Source / Purification
Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the carboxy terminus of human INSM1 protein.
Background
Insulinoma-associated protein 1 (INSM1), originally named IA-1, is a zinc-finger protein cloned from an insulinoma and glucagonoma subtraction library (1). It is a transcriptional repressor expressed in the developing pancreas and nervous system and targets genes such as NeuroD/β2 and insulin, critical regulators of neuroendocrine differentiation during development (2-5). Most importantly, INSM1 has emerged as a key marker in neuroendocrine tumor types, including small cell lung cancer (SCLC), medullary thyroid carcinoma, pheochromocytoma, Merkel cell carcinoma, neuroblastoma, and neuroendocrine tumors of the pancreas, breast, colon, bladder, and prostate (6-9). Some studies have also shown that the level of INSM1 expression may have prognostic value (10,11).
- Goto, Y. et al. (1992) J Biol Chem 267, 15252-7.
- Breslin, M.B. et al. (2002) Nucleic Acids Res 30, 1038-45.
- Wang, H.W. et al. (2008) J Endocrinol 198, 29-39.
- Gierl, M.S. et al. (2006) Genes Dev 20, 2465-78.
- Wildner, H. et al. (2008) Development 135, 473-81.
- Möller, K. et al. (2024) Mol Cell Endocrinol 581, 112106.
- Sakakibara, R. et al. (2020) Am J Surg Pathol 44, 757-764.
- Hou, T. et al. (2020) Cancer Cytopathol 128, 725-732.
- Mahalakshmi, B. et al. (2020) Cell Oncol (Dordr) 43, 367-376.
- Xu, X. et al. (2022) Pathol Res Pract 229, 153693.
- Razvi, H. et al. (2021) Pathology 53, 170-178.
限制使用
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For Research Use Only. Not for Use in Diagnostic Procedures.
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